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Videos: “Bioestadística para Vivir”

A set of online video tutorials recorded during the Cycle of Conferences “Bioestadística para Vivir” can be found here. These talks are aimed to the general public and try to show the impact of Biostatistics on everyday life, especially in the fields of health and the environment.

Biostatnet is one of the collaborating members of this project,“ Bioestadística para Vivir y Cómo Vivir de la Estadística”, which is promoted by the University of Santiago de Compostela, through its Unit of Biostatistics (GRIDECMB), and the Galician Institute of Statistics. This knowledge exchange initiative is funded by the Spanish Science & Technology Foundation (FECYT).

Other activities are being developed under this project; the exhibition Exploristica – Adventures in Statistics: an itinerant exhibition  teaching Statistics to secondary school students, Cycles of Conferences, Problem solving workshops, etc. You can find out more here .

 

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My impressions from the Workshop on the Future of the Statistical Sciences

An exciting workshop, organised as the capstone of the International Year of Statistics Statistics2013, was celebrated on the 11th and 12th of November at the Royal Statistical Society Headquarters in London, under the stimulating title of  “The Future of the Statistical Science”, science to which John Pullinger, president of the Royal Statistical Society, refers to as a quintessentially, multidisciplinary discipline. The workshop was indeed a good example of that.

Online attendance was welcomed to the event giving an additional opportunity to listen to highly reputed professionals in main areas of Statistics. Virtual participants were also allowed to pose their questions to the speakers, an innovation that worked very well as an excellent way to make these sorts of events available to a wider audience that would otherwise be excluded – I am already looking forward to more! -.

In case you missed it at the time, luckily the podcast is still available here.

True to its description, the event covered different areas of application, it showed the tools of the field for tackling a wide range of challenges, it portrayed potentially high impact examples of research, and in summary, was a great attention-grabbing exercise that will hopefully encourage other professionals to the area. A common vision of ubiquity and great relevance came across from the speeches and showed the field as a very attractive world to join. See my simplified summary below in form of a diagram certainly reflective of the great Statistics Views motto “Bringing Statistics Together”.

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Fig 1. Some of the ideas discussed in the workshop

Particularly relevant to this blog and my particular interests were presentations on environmental Statistics and statistical Bioinformatics, as well as other health-related talks. Important lessons were taken on board from the rest of the speakers too.

The workshop started with a shared presentation on the hot topic “Statistical Bioinformatics” by Peter Bühlmann (ETH Zürich) and Martin Vingron (Free University of Berlin). In a fascinating talk, Bühlmann argued for the need of uncertainty quantification in an increasingly heterogeneous data world –examples of this are also appearing in other fields, e.g. in the study of autism disorders as Connie Kasari and Susan Murphy mentioned in “SMART Approaches to Combating Autism”- and for models to be the basis of the assignation of uncertainties – topic greatly covered by Andrew Gelman in “Living with uncertainty, yet still learning”-, while acknowledging that in the big data context, “confirmatory statistical inference is (even more) challenging”. Vingron followed by focusing on “Epigenomics as an example”, raising open questions to the audience on how to define causality in Biology where “most processes […] are feedback circular processes”, calling for models that are just complex enough so as to allow for mechanistic explanations, and for good definitions of null hypotheses.

In addition to the interesting points of the talk, I found its title particularly attractive in what it could be directly linked to a vibrant roundtable on “Genomics, Biostatistics and Bioinformatics” in the framework of the 2nd Biostatnet General Meeting, in which, as some of you might remember, the definitions of the terms Biostatistics and Bioinformatics were discussed. I wonder if the term “statistical Bioinformatics” would be indeed the solution to that dilemma? As a matter of fact, Bühlmann himself mentions at the start of his talk other options like Statistical Information Sciences, etc-

Michael Newton and David Schwartz from the University of Wisconsin-Madison also focused on the triumph of sequencing and “Millimeter-long DNA Molecules: Genomic Applications and Statistical Issues”. Breast cancer being one of the mentioned applications, this was followed by an introduction to “Statistics in Cancer Genomics” by Jason Carroll and Rory Stark (Cancer Research UK Cambridge Institute, University of Cambridge), particularly focusing on breast and prostate cancer and the process of targeting protein binding sites.  The latter, as a computational biologist, mentioned challenges on the translation of Statistics for the biologists and vice versa, and identified ”reproducibility as (the) most critical statistical challenge” in the area – also on the topic of reproducibility, it is especially worth watching “Statistics, Big Data and the Reproducibility of Published Research” by Emmanuel Candes (Stanford University) -.

Another area increasingly gaining attention in parallel with technologies improvements is Neuroimaging. Thomas Nichols (University of Warwick) lead the audience in a trip through classical examples of its application (from Phineas Gage´s accident to observational studies of the structural changes in the hippocampi of taxi drivers, and the brain´s reaction to politics) up to current exciting times, with great “Opportunities in Functional Data Analysis” which Jane-Ling Wang (University of California) promoted in her talk.

Also in the area of Health Statistics, different approaches to dietary patterns modelling were shown in “The Analysis of Dietary Patterns and its Application to Dietary Surveillance and Epidemiology” by Raymond J. Carroll (Texas A&M University), and Sue Krebs-Smith (NCI), with challenges in the area being; finding dietary patterns over the life course – e.g. special waves of data would appear in periods like pregnancy and menarchy for women-, and incorporation of technology to the studies as a new form of data collection –e.g., pictures of food connected to databases-.

Again with a focus on the challenges posed by technology, three talks on environmental Statistics outlined an evolution over time of the field. Starting from current times, Marian Scott (University of Glasgow) in “Environment – Present and Future” stated in her talk that “natural variability is more and more apparent” because we are now able to visualise it. This idea going back to the heterogeneity claimed by Bühlmann. Despite the great amounts of data being available, and initially caused by technological improvements but ultimately due to a public demand – “people are wanting what it is happening now”-, the future of the field is still subject to the basic questions: “how and where to sample.” Especially thought-provoking were Scott´s words on “the importance of people in the environmental arena” and the need for effective communication: “we have to communicate: socio-economic, hard science…, it all needs to be there because it all matters, it applies to all the world…”

Amongst other aims of this environmental focus such as living sustainably – both in urban and rural environments-, climate is a major worry/fascination which is being targeted through successful collaborations of specialists in its study and statisticians. “Climate: Past to Future” by Gabi Hegerl (University of Edinburgh) and Douglas Nychka (NCAR) covered “Regional Climate – Past, Present and Future” and showed relevant examples of these successful collaborations.

Susan Waldron (University of Glasgow), under the captivating speech title of “A Birefringent Future”, highlighted the need to address challenges in the communication of “multiple layers of information” too, Statistics appearing as the solution for doing this effectively –e.g. by creating “accessible visualisation of data” and by incorporating additional environmental variation in controversial green energy studies such as whether wind turbines create a microclimate-. Mark Hansen (Columbia University Journalism School) seconded Waldron´s arguments and called for journalists to play an important role in the challenge: “data are changing systems of power in our world and journalists. […] have to be able to think both critically as well as creatively with data”, so as to “provide much needed perspective”. Examples of this role are; terms such as “computational Journalism” already being coined and data visualisation tools being put in place -as a fascinating example, the New York Times´ Cascade tool builds a very attractive representation of the information flow in Social Media-. David Spiegelhalter (Cambridge University) also dealt with the topic in the great talk “Statistics for an Informed Public”, providing relevant examples (further explanation on the red meat example can be found here as well).

To encourage “elicitation of experts opinions (to reach a) rational consensus” and “to spend more time with regulators” came up as other useful recommendations in the presentation “Statistics, Risk and Regulation” by Michel Dacorogna (SCOR) and Paul Embrechts (ETH Zürich).

In a highly connected world inmersed in a data revolution, privacy becomes another major issue. Statistical challenges arising from networked data –e.g. historical interaction information modelling- were addressed by Steve Fienberg (Carnegie Mellon University) and Cynthia Dwork (Microsoft Research), who argued that “statisticians of the future will approach data and privacy (and its loss) in a fundamentally algorithmic fashion”, in doing so explicitly answering the quote by Sweeney: “Computer science got us into this mess, can computer science get us out of it?”. Michael I. Jordan (University of California-Berkeley) in “On the Computation/Statistics Interface and “Big Data”” also referred to “bring(ing)  algorithmic principles more fully into contact with statistical inference“.

I would like to make a final mention to one of the questions posed by the audience during the event. When Paul Embrechts was enquired about the differences between Econometrics and Statistics, a discussion  followed on how crossfertilisation between fields has happened back and forth. As a direct consequence of this contact, fields rediscover issues from other areas. For instance, Credit Risk Analysis models were mentioned as being inferred from Medical Statistics or back in Peter Bühlmann´s talk, links were also found between Behavioural Economics and Genetics. These ideas, from my point of view, bring together the essence of Statistics, i.e. its application and interaction with multiple disciplines as the foundations of its success.

Many other fascinating topics were conveyed in the workshop but unfortunately, I cannot fit here mentions to all the talks. I am sure you will all agree it was a fantastic event.

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FreshBiostats´ First Anniversary

So here we are. It has been a year since we started this venture. The idea of a blog came up from one of our co-bloggers at the Jede II Conference in the summer of 2012.  At first it sounded like a bit of a challenge, but who said fear?

No doubt about it, the balance has been highly positive. We are all for sharing knowledge and resources that might be valuable for others, and from our humble perspective we sincerely hope it might have been of some use. It has certainly been so for us, both by getting insight into particular subjects when writing the different posts and by diving into new topics covered by our co-bloggers and invited posts. Twitter and facebook have also allowed us to encourage interaction with colleagues and other bloggers, and we can now say our social and professional networks have certainly become bigger and stronger!

We have found it difficult at times to juggle our jobs and PhDs with writing our weekly posts but as we said in several occasions, we are passionate about our work, and firmly believe that, most of the time, the line between work and fun gets blurry.

As we promised in a previous post, here is an infographic summarising this year of Fun & Biostatistics, enjoy!

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We have a very international audience with visits coming from 117 countries, and we are delighted to see that not only colleagues from our closest network are reading our entries. Since our participation on the International Statistics Year blog -Statistics2013- and after being mentioned in other blogs such as RBloggers and others, we have gained more visibility and some posts have become very popular (more than 1000 views for some!).

Those posts focusing on R tips clearly take the cake, being the most visited. We guess they might be the most useful ones, as we are also big fans of other very practical blogs. However we like to cover all the aspects of our profession and even sometimes deal with more controversial or philosophical subjects…

We will keep inviting people to share their knowledge and will encourage colleagues to get involved in the blog. Our second year resolution is to make an effort to make of this blog a more interactive tool. We count on you for that!

Remember you can contact us with your comments, suggestions, and enquiries at freshbiostats@gmail.com

Thank you so much for being there!

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FreshBiostats birthday and September-born famous statisticians

With the occassion of the 1st birthday of FreshBiostats, we want to remember some of the great statisticians born in September and that have contributed to the “joy of (bio)stats”.

Gerolamo Cardano Pavia, 24 September 1501 – 21 September 1576 First systematic treatment of probability
Caspar Neumann Breslau, 14 September 1648 – 27 January 1715 First mortality rates table
Johann Peter Süssmilch Zehlendorf, 3 September 1707 – 22 March 1767 Demographic data and socio-economic analysis  
Georges Louis Leclerc (Buffon) Montbard, 7 September 1707 – Paris, 16 April 1788 Premier example in “geometric probability” and a body of experimental and theoretical work in demography
Adrien-Marie Legendre Paris, 18 September 1752 – 10 January 1833 Development of the least squares method
William Playfair Liff, 22 September 1759 – London, 11 February 1823 Considered the founder of graphical methods of statistics (line graph, bar chart, pie chart, and circle graph)
William StanleyJevons Liverpool, 1 September 1835 – Hastings,13 August 1882 Statistical atlas – graphical representations of time series
Anders Nicolai Kiaer Drammen, 15 September 1838 – Oslo, 16 April 1919 Representative sample
Charles Edward Spearman London, 10 September 1863 – 17 September 1945 Pioneer of factor analysis and Spearman´s Rank correlation coefficient
Anderson Gray McKendrick Edinburgh, September 8, 1876 – May 30, 1943 Several discoveries in stochastic processes and collaborator in the path-breaking work on the deterministic model for the general epidemic
Maurice Fréchet Maligny, 2 September 1878 – Paris, 4 June 1973 Contributions in econometrics and spatial statistics
Paul Lévy 15 September 1886 – 15 December 1971 Several contributions to probability theory
Frank Wilcoxon County Cork, 2 September 1892 – Tallahassee, 18 November 1965 Wilcoxon rank-sum tests, Wilcoxon signed-rank test
Mikhailo Pylypovych Kravchuk Chovnytsia, 27 September 1892- Magadan, 9 March 1942 Krawtchouk polynomials, a system of polynomials orthonormal with respect to the binomial distribution
Harald Cramér Stockholm, 25 September 1893 – 5 October 1985 Important statistical contributions to the distribution of primes and twin primes
Hilda Geiringer Vienna, 28 September 1893 – California, 22 March 1973 One of the pioneers of disciplines such as molecular genetics, genomics, bioinformatics,…
Harold Hotelling Fulda, 29 September 1895 – Chapel Hill, 26 December 1973 Hotelling´s T-squared distribution and canonical correlation
David van Dantzig Rotterdam, 23 September 1900 -Amsterdam,  22 July 1959 Focus on probability, emphasizing the applicability to hypothesis testing
Maurice Kendall
Kettering, 6 September 1907 – London, 29 March 1983 Random number generation and Kendall´s tau
Pao-Lu Hsu Peking, 1 September 1910 – Peking, 18 December 1970 Founder of the newly formed discipline of statistics and probability in China

It is certainly difficult to think of the field without their contributions. They are all a great inspiration to keep on learning and working!!

Note: you can find other interesting dates here.

Update: and Significance´s timeline of statistics here.

Any author you consider particularly relevant? Any other suggestions?

Happy New (International Statistics) Year!

With the start of the new year last Tuesday, it is now time to make resolutions and plans for the 12 months ahead. For scientists and especially for those who are involved in statistical matters, it will be a special one, since 2013 has been declared as the International Year of  Statistics by the American Statistical Association, the Institute of Mathematical Statistics, the International Biometric Society, the International Statistical Institute (and the Bernoulli Society), and the Royal Statistical Society. This year commemorates major events that were determinant for the evolution of Statistics. As mentioned on the International Statistics Institute website, “2013 will be the 300th anniversary of Ars Conjectandi, written by Jakob Bernoulli and considered a foundational work in probability…  and the 250th anniversary of the first public presentation of Thomas Bayes’ famous work.”

 
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One of the FreshBiostats initial aims is to promote amongst young researchers, and within our limits, this science that is a complete unknown for many people, but plays at the same time a very important role in many other more popular fields -like Biology or Medicine in the particular case of Biostatistics.

It is with great pleasure that we find as one of the main objectives of Statistics2013 “nurturing Statistics as a profession, especially among young people”, and makes us very proud to be one of the participating groups supporting this and other also important goals. Hopefully, this initiative will contribute to the exponential trend that has been noticed in the interest of students towards this topic (you can find graphical representations of Harvard´s stat concentration enrollment here).

For further information, you can visit the website http://www.statistics2013.org/ and watch the launch video here.

We hope to make a significant contribution to this fantastic year, how will you take part in the celebration? Time is running out!!